search and download 34849 doctoral phd dissertations from sweden. In english. For free. can you take viagra 20 mg everyday Show downloadable dissertations only   do a more advanced search » soft tissue sarcoma patterns multiplicity, heterogeneity and growth characteristics university dissertation from institution of clinical sciences, lund universiy hospital author: josefin fernebro; lunds universitet. ; lund university. buy viagra online ; [2007] keywords: medicin; medicine; cytologi; cancerology; oncology; soft tissue sarcoma; tumor periphery; medicine human and vertebrates ; medicin mã¤nniska och djur ; cytology; multiple primary tumors; onkologi; cancer; abstract: soft tissue sarcomas (sts) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects? viagra coupon Pathological, genetical, and clinical? viagra soft flavored Of sts. In study i, we demonstrated that 20% of the patients in a population-based series of 818 sts developed second primary malignancies. viagra canada online An increased risk of developing a second malignancy was identified (smr 1. 3; 95% ci=1. 0-1. 5), with a particularly high risk of developing a second sts (smr 17. best place buy viagra online generic 6; 95% ci=8. 1-33. generic viagra 5). Study ii included 13 patients who had developed at least two primary sts and we applied array-based comparative genomic hybridization to study the genetic profiles of these tumors. viagra headquarters toronto snopes Cluster anaysis and comparison between the genetic profiles suggested that 8 cases represented second primary sts, whereas 5 cases likely represented soft tissue metastases. order viagra In study iii cdna microarray was applied to 26 synovial sarcomas and identified differentially expressed genes in relation to gene fusion type. viagra canada Among the discriminators were several genes that have previously been found to be up-regulated in ss, including axl, zic2, spag7, agrn, foxc1, ncam1. In study iv we assessed the impact of targeting peripheral versus central tumor areas using tissue microarray-based staining for ki-67 in leiomyosarcomas and demonstrated that the ki-67 expression was higher in the tumor periphery in 18/25 tumors. These observations suggest that ki-67 evaluation for prognostic purposes should be standardized regarding the part of the tumor investigated. viagra effects urdu In study v, peripheral tumor growth pattern was evaluated on preoperative mri with correlations to microscopical growth pattern and prognosis. All tumors with diffuse infiltration on mri also showed microscopical infiltration, whereas mri failed to identify infiltration in one-third of the microscopically infiltrative tumors. Diffusely infiltrative growth on mri correlated with prognosis with a 2. 5 times increased risk of metastases (p=0. 01) and a 3. viagra effects urdu 7 times higher risk of local recurrence (p=0. 02). In summary, we have demonstrated that patients with sts are at increased risk of developing second primary tumors, including sts, with genetic profiles supporting independent tumor origin. We have also demonstrated that the underlying gene fusion type in synovial sarco.
Pulsar para visitar la web